CURRICULUM VITAE AND BIBLIOGRAPHY

NAME: John E. McGinness, Ph.D., M.D.

PRESENT TITLE: Faculty, Northwood College

EMAIL: drjohn@organicmetals.com

PHONE: (713) 661-8036

BIRTHDATE: November 19, 1943

CITIZENSHIP: United States

UNDERGRADUATE EDUCATION:

B.S. Physics - University of Houston, 1966

GRADUATE EDUCATION:

Ph.D. Physics

Rice University, 1970

POSTGRADUATE TRAINING:

M,D.

Medical School - University of Texas at Houston, 1981-1985

Internship: Internal Medicine, 1985-1986 Residency:

Psychiatry, 1986-1989 ACADEMIC APPOINTMENTS:

Assistant Professor of Clinical Psychiatry, Department of Psychiatry, University of Texas Health Science Center at Houston - HCPC, 1989 - 1992

Assistant Physicist and Assistant Professor of Biophysics, The University of Texas M.D. Anderson Hospital and Tumor Institute, Houston, Texas, 1970 - Present/Consultant

Assistant Professor of Metallurgy and Materials Science, Youngstown State University, Youngstown, Ohio, 1970 - 1972

HOSPITAL APPOINTMENTS:

Harris County Psychiatric Center, 1989 - 1992

HONORS AND AWARDS:

MEDICINE

Achieved the first definition of a adjuvant modality for malignant melanoma based on the anomolously high absorption of ultrasound by melanin.

Achieved the first enzymatic amelioration of the dose limiting toxicity of Cis-Platinum and adriamycin in an animal system.

Achieved an increase in the therapeutic index of Adriamycin with Hydroxyethyl Ruticide in CDF mice bearing L 1210 Leukemia.

OPHTHALMOLOGY

Developed the first in Vivo model for retinal degeneration induced by the free radical generating anticancer drug adriamycin, the rate of retinal degeneration is strongly age dependent.

Developed a rule for combining Lithium and Carbamazepine and avoiding neurotoxicity.

BASIC SCIENCE

Discovered amorphous semi-conductor switching in melanins. NB: This device is now in the Smithsonian Chips Collection of the American Museum of History.

Co-discoverer of the anomalous absorption of ultrasound by melanin (Kono, R., McGinness, J.E.) .

BIOLOGY

Defined the first model for a physiological role for melanosomes in the eye and mid-brain.

PHYSICS

Co-discoverer of a possible advantage of low mobility in minimizing wave packet spread.

TEACHING BACKGROUND:

3 quarter hours, 3 quarters - Introduction to the Properties of Materials as they Respond to Physical Interactions.

3 quarter hours, 3 quarters - Chemical Principles of Solid-Liquid Interactions and Their Role in Forming and Changing the Physical Properties of Materials.

4 quarter hours, 2 quarters - Atomic and Molecular Structure of Materials and Their Relation to the Quantum Behavior of the Constituent Atoms and Molecules.

3 quarter hours, 6 quarters - Particle Interactions - An Introduction to the Nuclear Particles and Their Reactions.

3 quarter hours, 2 quarters - Introduction to the Selection and Structural Processing of Fabrication of Materials for use in Nuclear Reactors.

4 quarter hours, 2 quarters - Thermodynamics of Materials and the Relation Between the Microscopic of Quantum World and Macroscopic.

3 quarter hours, 2 quarters - Quantum Calculations of Solid State Properties as they Exist in Crystalline Systems.

1 quarter hour, 2 quarters - Biophysics Seminar. Selected topics for Graduate Students at M.D. Anderson.

Student Interview Course MSII. Differential Diagnosis MSIII.

SERVICE ON NATIONAL GRANT REVIEW PANELS, STUDY SECTIONS, COMMITTEES:

FDA Study Section Free Radical Damage in Vision, 1984

SERVICE ON THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT HOUSTON COMMITTEES:

Student Education Committee Infectious Disorder Committee Affective Disorder Committee

SERVICE ON GRADUATE SCHOOL COMMITTEES:

Resident Education Committee

TEACHING RESPONSIBILITIES:

Interview Course MSIII DDX, 1 hour MSIII

PAST GRANT SUPPORT:

NIH - MDA, 1975 Co-principal Investigator. BRSG MDA, 1981

PUBLICATIONS:

ABSTRACTS

McGinness, J.E. and Corry, P.M.: Ultrasound drug interactions in human melanoma cells. Xlth Int. Cancer Cong.. 1974

Corry, P.M. and McGinness, J.E.: Exploitation of amorphous semi conductivity to preferential killing of melanoma cells. Xlth Int. Cancer Cong.. 1974

Proctor, P.H. and McGinness, J.E.: Quantum mechanical aspects of the treatment of melanotic tumors. Xlth Int. Cancer Cong., 1974.

McGinness, J.E.: Effects of charge transfer agents on amorphous semiconductor switching in melanins. Biochem. and Biophys. Meeting, 1974.

Amour, E., Corry, P.M., and McGinness, J.E.: Ultrasonic effects on melanoma cells in culture. Biophys. J. 15:64a, 1975

McGinness, J.E. and Corry, P.M.: Melanin binding drugs and ultrasonic induced cytotoxicity. IX. Int. Pigment Cell Conf.. 1975.

Corry, P.M. and McGinness, J.E.: Semiconductor properties of melanins IXth Int. Pigment Cell Conf.. 1975.

Proctor, P.H., KirfcpatricJc, D.S., McGinness, J.E., and Corry, P.M.: Stimulated conductivity (threshold switching) in isolated photo reception membranes. Biophys. Society, 20th Annual Meeting, 1976.

Proctor, P.H., Kirkpatrick, D.S., McGinness, J.E., and Corry, P.M.: Amorphous semiconductor switching in photoreceptor membranes. Assoc. for Res, in Vision Opthal. Annual Meeting. 1976.

Kirkpatrick, D.S., McGinness, J.E., Corry, P.M., Moorhead, W., Garza, H.M., and Proctor, P.M.: Water-photo receptor membrane interaction. Biophys. J. 17:2, 18a, 1977.

Armour/ E., Corry, P.M. and McGinness, J.E.: Preferential cytotoxicity of cultured melanoma cells by ultrasound and melanin binding drugs. Radiation Research 70690-691, 1977.

Kirkpatrick, D.S. and McGinness, J.E.: Dielectric measurements on rod outer segments. Biophys. Meeting,. 1977.

Kirkpatrick, D.S. and McGinness, J.E., Moorhead, W.D., and Corry, P.M.: Conditions for reproducible measurements in melanins. Xth Int. Pigment Cell Conf.. 1977.

McGinness, J.E., and Kono, R.: Melanosome cytoprotective or cytotoxic? Xth Int. Pigment Cell Conf., 1977.

McGinness, J.E., Proctor, P.M., Hokanson, J.S., Demopoulos, H.B., Pietronigro, D.D., and Kirkpatrick, D.S.: Superoxide dismutase and catalase studies of adriamycin and cis-platinum toxicity in the rat. Annual Meeting of Southwest Sec. Amer. Ass, for Cancer Res.f 1978.

McGinness, J.E., McConnell, P.: Finite Chaotic Oscillators, Chaotic Resonance and EEC's, Conference on Bio-Medical Engineering Research in Houston, Eicrhth Annual Conf.. 1990.

McGinness, J.: The glutamate-dopamine dual radical connection to neuromelanin. Pigment Cell Research Bulletin, European Society For Pigment Cell Research. No. 8, 1989.

REFERSED ORIGINAL ARTICLES IN JOURNALS:

McGinness, J.E., and Proctor, P.: The importance of the fact that melanin is black. J. Theor. Biol. 39:677-678, 1973.

McGinness, J.E., Corry, P.M., and Proctor, P.: Amorphous semiconductor switching in melanins. Science 183:853-855, 1974.

Proctor, P., McGinness, J.E., and Corry, P.M.: A hypothesis on the preferential destruction of melanized tissues. J. Theor. Biol. 48:19, 1974.

Mizutani, U., Massalski, T., McGinness, J.E., and Corry, P.: Anomalous low temperature specific heat results in melanins and intact melanosomes. Nature 259:505, 1976.

Filatovs, J., McGinness, J.E., Corry, P.M.: Thermal and electronic contributions to switching in melanins. Biopolymers 15:2309-2313, 1976.

Proctor, P., Kilpatric/c, D., and McGinness, J.E.: A superoxide producing system in the conjunctival mucus thread. Invest. Qphthalmol. Visual Sci. 8:762, 1977.

Moorhead, IV., McGinness, J.E., and Proctor, P.: An advantage to low electronic mobility in biological systems. Physiol. Chem. & Phys. 9:563-567, 1977.

Kono, R.H., Yoshizaku, Yamakoa, T., and McGinness, J.E.: Polymer Perprints, Japan 26/241-246, 1977.

Procter, P. Kirkpatrick , D.S., and McGinness, J.E.: Superoxide dismutase therapy in hyperuricaemic syndromes. Lancet, pp. 95, July 1978,

McGinness, J.E., Proctor, P.M., Demopoulos, H.B., Hokanson, J.A., and Kirkpatrick, D.S.: Amelioration of cis_-platinum nephrotoxicity by Orgotein (superoxide dismutuse). Physiol. Chem. and Phys. 10:267-277, 1978.

McGinness, J.E., Demopoulos, H.B., Proctor, P.H., and Kirkpatrick, D.S., Superoxide dismutase and catalase treatment of cis-platinum and adriamycin toxicity. Physicol. Chem. & Phys. 10(3), 1978.

Kirkpatrick, D., McGinness, J.E., Moorhead, W., Corry, P.M., and Proctor, P.: High frequency dielectric spectroscopy of concentrated membrane suspension. Biophys. J. 24:243-245, 1978.

Kirkpatrick, D.S., McGinness, J.E., Moorhead, W.D., and Corry, P.M.: Conditions for reproducible measurements in melanins. Xth Int. Pigment Cell Conf.. Pigment Cell 4:257-262, 1979.

McGinness, J.E., Kono, R., and Moorhead, W.D.: Melanosome: Cytoprotective or Cytotoxic? Pigment Cell, 4:270-276, 1979.

Kono, R. and McGinness, J.E.: Anomalous Absorption and Sound in DBA Melanins. J. Applied Physics, 50(3): 1236-1244, 1979.

McGinness, J.E., Crippa, P.R., Kirkpatrick, D.S., and Proctor, P.M.: Reversible and Irreversible Changes in Hydrogen Ion Titration Curves of Melanins. Physiol. Chem. and Phvs. 11:217-223, 1979.

Filatovs, G.J., McGinness, J.E., Williams, L.: Statistical Analysis of Switching Melanins. Physicol. Chem. and Phys. Vol. 12, No. 5, 1980.

Pietronigro, D.D., McGinness, J.E., Koren, M.J., Crippa, R., Seligman, M.L., and Demopoulos, H.B.: Spontaneous Generation of Adriamycin Semiguinone Radicals at Physiological H. Physiol. Chem. and Phys. 11 (5):405-414, 1979.

McGinness, J.E., Demopoulos, H.B., Hokanson, J.A., Proctor, P.H., and Kirkpatrick, D.S.: Enzymatic Evidence for Free Radical Production by Cis-platinum in Vivo. Xllth. Cancer Cong. Proc., 1978.

Kirkpatrick, D.S., McGinness, J.E., Moorhead, W.D., Corry, P.M., and Proctor, P.H.: Melanin-Water-Ion Dielectric Interaction. Pigment Cell Vol. 4p. 257-262, Karger Basel, 1979.

Gulati, O.P., Nordmann, H., Aelling, A., Maignan, M.F., and McGinness, J.E. Protective Effects of O-(Hydroxyethyl)-Rutosides (HR) Against Adriamycin-Induced Toxi city in Rats. Archives Internationales de Pharmacodynamie et de Therapie, Vol, 273, No. 2, 1985.

McGinness, J.E.: A New View of Pigmented Neurons. J. Theor. Biol. 115, 475-476, 1985.

Proctor, P.M., Kirkpatrick, D.S., and McGinness, J.E.: Superoxide Radical Production of Homocysteine in Plasma. Proceedings American Aging Association (in submission).

McGinness, J.E., Grossie, B., Benjamin, R., Hokanson, J.A.: The Effects of Dose Schedule of Vitamin E and Hydroxyethyl Ruticide on Mortality Induced by Adriamycin Cancer Research. Phys. Chem. Phys. and NMR 18 (1986) pp. 17-24.

Kretzer, F., McGinness, J.E., Drug Induced Retinal Atrophy in the Rat, 4th Int. Symposium of Structure of the Eye. Elsevier North Holland.

Baker, Dayhaw, P., Felton, R., forbes, D., Fox, D., McGinness, J.E., and McGraw, J.: Photosynsetized Interocular Damage. Academic Press. 1984.

Proctor, P.H. and McGinness, J.E.: The Function of Melanin. Arch Dermatol. V122, May 1986.

McGinness, J.E.: Free Radicals and the Development Pathology of Schizophrenic Burnout. Integrative Psychiatry. 1987.

Effect of Dose Schedule of Hydroethyl Ruticide (Venoruton) on Toxicity Induced by Adriamycin Presented at the 1984 Meeting of the American Association of Cancer Research, Toronto, Canada.

INVITED LECTURES:

Acoustical Society of America, University of Houston, February 1975. Drug Ultrasound Interactions.

New York University Medical Center, Pathology Department, June 1975. Preferential Killing of Melanized Tissue.

Physics Department, University of Houston. Amorphous Semiconductor Physics in Biological Materials.

Physics Department, Youngstown State University. Dielectric Spectroscopy Measurements on Melanins, September 1976.

New York University Medical Center, Pathology Department, October 1977. "Free Radical Mechanisms in Cis-platinum Nephrotoxicity."

Proceedings of the conference "Melanin in the Midbrain," Mobile, Alabama, January 1979.

A Physiological Role for Melanin in the Eye and Midbrain.

Proceedings of the "Second International Conference on Superoxide Dismutase, February, 1979, Hawaii. Enzymatic Management of Toxicity Induced by Superoxide Anion Producing Chemotherapy Agents.

Dermatology Institute Palermo Sicily. "Biological Mechanisms of Action for Melanins in Living Systems." August 1982.

Zyma Pharmaceuticals Conference on HR. Nyon, Switzerland. Dose and Schedule Dependence of Antioxidants in Amelioration of GI Mucosidis. 1982.

Plenary Lecture.

P.H. Proctor, J.E. McGinness. Superoxide Production by Homocysteine in Plasma. American Aging Association Annual Meeting. New York, October 1984.

Biomedical Engineering Research in Houston, "Finite Chaotic Oscillators, Chaotic Resonance and EEC's."

McGinness, J.E., and McConnell, P., Harris County Psychiatric Center, February 1990.University of Texas Medical School at Houston, Clinical Neurobiology of Mania,

McGinness, J.E., "Analysis of Pharmacologic Interactions Between Lithium and Anticonvulsants," February 1990.

BOOKS:

McGinness, J.E., Corry, P.M., and Armour, E.: Melanin binding drug and ultrasonic induced cytotoxicity. Proc. XI. Internat. Pigment Cell Conf. pp. 321-326, 1975.

Corry, P., McGinness, J.E., and Armour, E.: Semiconductor properties of melanins related to preferential killing of melanoma cells. Proc. XI. Internat. Pigment Cell Conf. pp. 321-326, 1975.

McGinness, J.E. and Proctor, P.H.: In Vivo Probe for Superoxide and Peroxide Production by Anit-Cancer Drugs. Ann Autor Ed. Pathology of Oxygen, Academic Press. 1982.

McGinness, J.E.: Chaos in the Human Brain. Analysis of EKG Abnormalities in Patients With Focal Hypoperfusion Confirmed by SPECT